(7-hydroxy-5-phenethyl[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine
Enarodustat; JTZ-951; JTZ 951; JTZ951
CAS: 1262132-81-9
Molecular Formula: C17H16N4O4
(7-hydroxy-5-phenethyl[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine - Names and Identifiers
(7-hydroxy-5-phenethyl[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine - Physico-chemical Properties
| Molecular Formula | C17H16N4O4 |
| Molar Mass | 340.33 |
| Density | 1.44±0.1 g/cm3(Predicted) |
| pKa | 0.58±0.53(Predicted) |
| Storage Condition | -20℃ |
| Use | Enarodustat is an effective, orally available factor prolyl hydroxylase inhibitor, EC50 of 0.22 μM. Enarodustat has the potential to be used in the study of renal anemia. |
(7-hydroxy-5-phenethyl[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.938 ml | 14.692 ml | 29.383 ml |
| 5 mM | 0.588 ml | 2.938 ml | 5.877 ml |
| 10 mM | 0.294 ml | 1.469 ml | 2.938 ml |
| 5 mM | 0.059 ml | 0.294 ml | 0.588 ml |
Last Update：2024-01-02 23:10:35
(7-hydroxy-5-phenethyl[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine - Reference Information
| biological activity | Enarodustat (JTZ-951) is a potent, the IC50 value for PHD2 was 0.22 μm and the EC50 value for EPO release from Hep3B cells was 5.7 μm. Enarodustat has the potential to treat renal anemia. |
| Target | Value |
| PHD2 (Cell-free assay) | 0.22 μM |
| EPO release from Hep3B cells (Cell-based assay) | 5.7 μM(EC50) |
Last Update：2024-04-09 15:16:57
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Spot supply
Product Name: Enarodustat Visit Supplier Webpage Request for quotationCAS: 1262132-81-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Enarodustat; JTZ-951; JTZ 951; JTZ951 Visit Supplier Webpage Request for quotationCAS: 1262132-81-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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